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Autodata Limited is a British multinational[1] that specialises in automotive data and software. Autodata provides automotive technical information to professionally service, maintain, and repair cars, light commercial vehicles, and motorcycles. It's best known[2] for providing the automotive aftermarket with OE manufacturer data.
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Abstract:This article outlines methods to facilitate the assessment of the impact of electric vehicle charging on distribution networks at planning stage and applies them to a case study. As network planning is becoming a more complex task, an approach to automated network planning that yields the optimal reinforcement strategy is outlined. Different reinforcement measures are weighted against each other in terms of technical feasibility and costs by applying a genetic algorithm. Traditional reinforcements as well as novel solutions including voltage regulation are considered. To account for electric vehicle charging, a method to determine the uptake in equivalent load is presented. For this, measured data of households and statistical data of electric vehicles are combined in a stochastic analysis to determine the simultaneity factors of household load including electric vehicle charging. The developed methods are applied to an exemplary case study with Norwegian low-voltage networks. Different penetration rates of electric vehicles on a development path until 2040 are considered.Keywords: electric vehicles; genetic algorithm; power demand; power systems analysis computing; power system planning; probabilistic network planning; statistical analysis
Background: Because Hematopoietic Cell Transplants (HCTs) carry risks of specific complications, require a peculiar hospital organization that entails tight collaborations between various specialties, and were never granted a marketing authorization, EBMT pioneered long-term follow-up in real-world conditions of these procedures. This lead to the establishment of a registry that today collects information from more than 600 transplant programs established in Europe and beyond, and contains data on more than 700.000 transplants. Innovative hematopoietic cellular therapies that are regulated as medicinal products (MP) are now entering the market at an accelerated pace, raising new hopes for patients and families. These include Immune Effector Cells (IEC), the most publicized being Chimeric Antigen Receptor (CAR)-T cells. These gene therapy MPs induce responses in a significant proportion of patients affected with relapsed/refractory lymphoid malignancies at advanced stages, but also carry significant risks to the patients. They are living drugs with effects that can persist for extended periods of time. They are manufactured through viral engineering of autologous T cells isolated from blood mononuclear cells, and thus qualify as genetically modified organisms. The manufacturing process takes advantage of infrastructures and expertise that are similarly used for HCTs, including cell collection and cell processing facilities. CAR-T cells are among the most expensive MP ever marketed. In view of these features, the EBMT registry appears ideally suited to contribute to the long-term follow-up of patients treated with CAR-T cells, as mandated by health authorities.
Background: Patients with high-risk ALCL are often referred for autologous (auto) and/or allogeneic (allo) HCT for curative intent. However, there are limited data available to guide transplant-related decision making outside of multi-site or registry studies. 2ff7e9595c
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